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Cerebrospinal fluid monoamine metabolites in narcolepsy and hypersomnia
Author(s) -
Faull Kym F.,
Guilleminault Christian,
Berger Philip A.,
Barchas Jack D.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410130306
Subject(s) - homovanillic acid , narcolepsy , probenecid , cerebrospinal fluid , monoamine neurotransmitter , dopamine , excessive daytime sleepiness , medicine , anesthesia , psychology , endocrinology , modafinil , psychiatry , sleep disorder , insomnia , serotonin , receptor
Two groups of patients with the common complaint of excessive daytime sleepiness were examined. One group fulfilled the criteria for narcolepsy. The other had the sole symptom of excessive daytime sleepiness, confirmed by sleep latency tests, which was unaccompanied by systemic illness. Spinal fluid examinations for homovanillic acid, 3,4‐dihydroxyphenylacetic acid, 3‐methoxy‐4‐hydroxyphenylethylene glycol, and 5‐hydroxyindoleacetic acid were carried out before and after administration of probenecid on the 20 patients and 40 controls. Probenecid‐corrected accumulation of the dopamine metabolites was significantly increased in each of the patient groups, suggesting an association between pathological sleepiness and elevated dopamine turnover in the central nervous system.