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The comparative effects of organic brain disease on cerebral blood flow and measured intelligeence
Author(s) -
Butler Robert W.,
Dickinson William A.,
Katholi Charles,
Halsey James H.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410130208
Subject(s) - cerebral blood flow , wechsler adult intelligence scale , dementia , raw score , brain disease , disease , abnormality , medicine , psychology , cardiology , degenerative disease , audiology , psychiatry , raw data , cognition , statistics , mathematics
Abstract Raw scores for cerebral blood flow (CBF), determined by xenon 133 inhalation, and for Wechsler Adult Intelligence Scale (WAIS) were measured in five groups of 12 subjects each: young normals, aged normals, and patients with cerebrovascular disease without dementia, dementia with cerebrovascular disease, and degenerative brain disease. Important differences were present in the raw data according to age and sex. When these were adjusted a quadratic model revealed a highly significant ( p < 0.0001, r = 0.86) correlation between CBF and measured intelligence score. We interpret these findings to indicate that in dementing illnesses the WAIS raw score reflects the severity of the brain disorder, regardless of cause, and that CBF is reduced as a function of the severity rather than the cause of the abnormality.