Premium
Interictal cerebral glucose metabolism in partial epilepsy and its relation to EEG changes
Author(s) -
Engel Jerome,
Kuhl David E.,
Phelps Michael E.,
Mazziotta John C.
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410120603
Subject(s) - ictal , hypermetabolism , electroencephalography , epilepsy , positron emission tomography , abnormality , medicine , partial epilepsy , neuroimaging , neuroscience , cardiology , psychology , radiology , psychiatry
Abstract Interictal positron computed tomography (PCT) with 18 F‐fluorodeoxyglucose was performed on 50 patients with partial seizure disorders. Electroencephalographic (EEG) monitoring was carried out during the metabolic studies using scalp and sphenoidal electrodes in 33 patients and stereotaxically implanted depth electrodes in 17. Four patients in this series had focal abnormalities on x‐ray computed tomographic scans, but these were at the site of the presumed epileptogenic lesion in only 2. One or more discrete zones of hypometabolism were identified in 35 patients, and only 1 patient appeared to show focal interictal hypermetabolism. No quantitative relationship could be demonstrated between the degree of focal hypometabolism and either the frequency of intericatal EEG spikes or the presence of focal nonepileptifor EEg changes. It was concluded that metabolic and electrophysiological techniques measure different aspects of cerebral dysfunction in seizures diorders. Although interictal PCT in patients with partial epilepsy usually demonstrates zones of hypometabolism, this finding, perŕse, does not reveal the epileptic nature of the abnormality.