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Correlation of isotopic cisternographic patterns in multiple sclerosis with CSF IgG values
Author(s) -
Bartolini S.,
Inzitari D.,
Castagnoli A.,
Amaducci L.
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410120514
Subject(s) - cerebrospinal fluid , amyotrophic lateral sclerosis , multiple sclerosis , abnormality , pathology , medicine , dementia , immunology , disease , psychiatry
Thirty‐eight patients with multiple sclerosis (MS) were examined with isotopic cisternography (IC) in order to study cerebrospinal fluid (CSF) dynamics. Cisternography was also performed in 15 patients with amyotrophic lateral sclerosis and in 14 with senile dementia of the Alzheimer type as controls. IC pattern of “mixed” type was found in 18 MS patients and all those with Alzheimer senile dementia examined, while the IC examination did not show abnormality in any of 15 patients with amyotrophic lateral sclerosis. In MS patients with amyotrophic lateral sclerosis. In MS Patients, the abnormal IC picture proved to be significantly correlated with the CSFIgG values as calculated by Link's and Tourtelotte's formulas. The abnormal IC in MS may be due to altered CSF reabsorption or increased transependymal flow, or it may be related to the abnormal concentration of IgG.