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Imparied biotin status in anticonvulsant therapy
Author(s) -
Krause KlausHenning,
Berlit Peter,
Bonjour JeanPierre
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410120513
Subject(s) - primidone , carbamazepine , phenytoin , biotin , anticonvulsant , medicine , epilepsy , pharmacology , plasma levels , gastroenterology , chemistry , biochemistry , psychiatry
Abstract In 264 epileptics undergoing long‐term therapy with anticonvulsants, significantly reduced plasma biotin levels were found compared with a normal control group: 74% of the epileptics had biotin levels for those treated with sodium valproate were higher than for those treated with phenytion, primidone, or carbamazepine. The observed reduction in biotin levels might be a factor influencing the efficacy of these three antionvulsants.