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Effect of folic acid and vitamin B 12 deficiencies on 5‐hydroxyindoleacetic acid in human cerebrspinal fluid
Author(s) -
Botez M. I.,
Young Simon N.,
Bachevalier Jocelyne,
Gauthier Serge
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410120512
Subject(s) - 5 hydroxyindoleacetic acid , cerebrospinal fluid , vitamin b12 , folic acid , polyneuropathy , depression (economics) , medicine , central nervous system , gastroenterology , endocrinology , serotonin , receptor , economics , macroeconomics
Indoles were measured in cerebrospinal fluid (CSF) from control patients, from patients suffering from folate deficiency, and from patients with vitamin B 12 deficiency. The folate‐deficient patients were classified according to whether they exhibited a neuropsychiatric syndrome, consisting of organic mental changes, polyneuropathy, and depression, which responded to folate administration. CSF 5‐hydroxyindoleacetic acid was low in the vitamin B 12 ‐deficient patients and in those folate‐deficient patients whose neuropsychiatric signs were responsive to folate administration, but was normal in the folate‐deficient patients whose symptoms were not related to folate deficiency. CSF 5‐hydroxyindoleacetic acid returned to normal with folate treatment in the patients exhibiting folate‐responsive neuropsychiatric signs. The data indicate a close association between folate‐responsive neuropsychiatric symptoms and change in 5‐hydroxytryptamine metabolism in the central nervous system.