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Spinocerebellar degeneration secondary to chronic intestinal malabsorption: A vitamin E deficiency syndrome
Author(s) -
Harding A. E.,
Muller D. P. R.,
Thomas P. K.,
Willison H. J.
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410120503
Subject(s) - vitamin e deficiency , malabsorption , medicine , ataxia , dysarthria , endocrinology , gastroenterology , proprioception , vitamin e , audiology , biology , physical therapy , biochemistry , psychiatry , antioxidant
Two adults are described who developed a progressive neurological disorder more than 20 years after the onset of chronic fat malabsorption. The clinical features included dysarthria, cerebellar ataxia, and prominent proprioceptive loss with depressed or absent tendon reflexes. Serum vitamin E was undetectable in both cases. One patient improved clinically and electrophysiologically after oral therapy with vitamin E. The findings in these patients were similar to those in others recently reported with vitamin E deficiency associated with biliary atresia. Electrophysiological observations suggested that the human deficiency state parallels that found neuropathologically in vitamin E‐deficient animals.