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A placebo‐controlled trial shows no effect of vasopressin on recovery from closed head injury
Author(s) -
Reichert Walter H.,
Blass John P.
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410120412
Subject(s) - vasopressin , placebo , rehabilitation , closed head injury , amnesia , medicine , clinical trial , anesthesia , head injury , psychology , physical medicine and rehabilitation , physical therapy , traumatic brain injury , psychiatry , alternative medicine , pathology
Vasopressin and its analogues have been claimed to benefit patients with posttraumatic amnesia. To test this hypothesis a double‐blind, placebo‐controlled, prospective trial of vasopressin was carried out in the chronic (rehabilitation) phase of recovery from closed head injury. Seven patients who received vasopressin and 6 who received a placbo were comparable in age, sex, and degree of disability upon entry into the study. Both groups inproved at the same rate in mental status, neurological status, and activities of daily living.