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Local cerebral glucose utilization in the newborn macaque monkey
Author(s) -
Kennedy C.,
Sakurada O.,
Shinohara M.,
Miyaoka M.
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410120404
Subject(s) - midbrain , macaque , white matter , brainstem , cerebellum , inferior colliculus , superior colliculus , anatomy , biology , visual cortex , grey matter , cerebral cortex , striate cortex , central nervous system , neuroscience , medicine , magnetic resonance imaging , nucleus , radiology
The [ 14 C]dexyglucose method for quantitative determination of local cerebral glucose utilization was employed in newborn macaque monkeys. Values ranged from a high of 180 μmol/100 gm/min in the inferior colliculus to a low of 14 μmol/100 gm/min in the centrum ovale, a wider range than had been found in this laboratory for pubescent monkeys. Relatively low values in white matter overlapped with the generally higher values in gray matter. Rates for structures in the lower neuraxis were equal to or exceeded those reported for the mature animal, while those above the midbrain were generally lower. The auditory system was unique in having rates equal to, or exceeding, its mature levels in all parts of the pathway including the cortex. In the visual system, subcortical structures were at their mature levels while rates in the cortical areas were variably low; nevertheless, the striate cortex had differential rates marking the various laminae. It was possible to demonstrate the metabolic counterpart of the ocular dominance columns in two newborn animals that had had one eye occluded during the experiment. Rates for white matter were above their mature levels, with the differences being greatest in the brainstem and cerebellum. A high correlation between glucose utilization and local blood flow measured with [ 14 C]antipyrine ( r = 0.92) was found.