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Concanavalin a binding of the cell surface of Duchenne muscle in vitro
Author(s) -
HeimanPatterson Terry D.,
Bonilla Eduardo,
Schotland Donald L.
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410120317
Subject(s) - concanavalin a , duchenne muscular dystrophy , skeletal muscle , itga7 , cell , myocyte , muscular dystrophy , in vitro , chemistry , biology , anatomy , pathology , endocrinology , medicine , biochemistry
Ultrastructural examination of concanavalin A (Con A) binding sites in cultured skeletal muscle from six patients with Duchenne muscular dystrophy (DMD) revealed no abnormalities at the cell surface when compared to normal cultured skeletal muscle. Reaction product at the cell surface appeared regular and continuous in both normal and dystrophic cultured muscle cells. These findings indicate that the abnormalities of Con A surface binding found in biopsied muscle of DMD are not present in aneurally cultured dystrophic muscle cells.