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Necrotizing arteritis and spinal subarachnoid hemorrhage in Sjögren syndrome
Author(s) -
Alexander Elaine L.,
Craft Carolyn,
Dorsch Carole,
Moser Robert L.,
Provost Thomas T.,
Alexander Garrett E.
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410110614
Subject(s) - medicine , vasculitis , arteritis , subarachnoid hemorrhage , necrotizing vasculitis , pathology , cryoglobulinemia , systemic disease , immunology , immunopathology , disease , hepatitis c virus , virus
A 37‐year‐old woman with primary Sjögren syndrome developed mixed cryoglobulinemia and systemic vasculitis. Subarachnoid hemorrhage occurred as a result of necrotizing anterior spinal arteritis. Although rarely seen in mixed cryoglobulinemia, central nervous system complications have recently been documented in Sjögren syndrome. The patient's serum contained antibodies to the Ro(SSA) cytoplasmic antigen, and these antibodies were concentrated in the cryoglobulin fraction. Anti‐Ro(SSA) antibodies are associated with the occurrence of vasculitis in patients with Sjögren syndrome, which suggests that the spinal arteritis and subarachnoid hemorrhage in this patient may have been directly related to the underlying connective tissue disorder.