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Dopaminergic deficiency and delayed visual evoked potentials in humans
Author(s) -
BodisWollner Ivan,
Yahr Melvin D.,
Mylin Leland,
Thornton John
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410110507
Subject(s) - carbidopa , dopaminergic , neuroscience , blockade , levodopa , visual evoked potentials , neurotransmitter , dopamine , medicine , evoked potential , dopamine receptor , latency (audio) , psychology , anesthesia , parkinson's disease , central nervous system , receptor , disease , electrical engineering , engineering
Abnormal delay in visual evoked potential (VEP) could be normalized in 9 of 14 previously untreated parkinsonian patients under the influence of levodopa/carbidopa therapy. In 6 of 11 previously untreated schizophrenic patients the VEP latency became abnormal following therapy with agents known to cause dopaminergic blockade. Besides defects in retrobulbar conduction secondary to demyelination, synaptic dysfunction due to neurotransmitter deficiency or receptor blockade must also be considered as a mechanism underlying VEP delays in humans.