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Acute conduction block associated with experimental antiserum‐mediated demyelination of peripheral nerve
Author(s) -
Sumner Austin J.,
Saida Kyoko,
Saida Takahiko,
Silberberg Donald H.,
Asbury Arthur K.
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410110506
Subject(s) - antiserum , peripheral , peripheral nerve , neuroscience , medicine , block (permutation group theory) , nerve conduction , pathology , immunology , anatomy , psychology , antibody , mathematics , combinatorics
Intraneural injection of antisera from rabbits with high antigalactocerebroside antibody levels into rat sciatic nerve produced acute nerve conduction block. This was first apparent in some motor axons between 30 and 60 minutes after injection and progressed to completion within 2 to 4 hours. Concurrent morphological evidence of demyelination was present, but structural changes at the time of onset of block were mild and were restricted to the myelin and Schwann cell, particularly at the paranodal areas and Schmidt‐Lanterman clefts. It is suggested that paranodal lesions could account for the observed conduction block.