Premium
PPD‐, PWM‐, and PHA‐induced interferon in stable multiple sclerosis: Association with HLA‐DW2 antigen and clinical variables
Author(s) -
Salonen Reijo,
Ilonen Jorma,
Reunanen Mauri,
Nikoskelainen Jukka,
Salmi Aimo
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410110308
Subject(s) - pokeweed mitogen , interferon , multiple sclerosis , human leukocyte antigen , immunology , antigen , stimulation , medicine , correlation , biology , in vitro , peripheral blood mononuclear cell , genetics , geometry , mathematics
Interferon production after stimulation of lymphocytes with purified protein derivative, pokeweed mitogen, and phytohemagglutinin was studied in 39 patients with stable multiple sclerosis (MS) and 39 age‐ and sex‐matched controls. Stable MS patients produced less interferon, and the number of subjects producing undetectable amounts of interferon was higher in the MS group (11/39) than in the control group (2/39). A tendency toward an association between low interferon production and HLA‐Dw2 antigen was found in MS patients. There was no clear‐cut correlation between interferon production and the duration of disease or disability of the patients. Although there was no systematic correlation of age with interferon, production patients older than 55 years tended to be very poor interferon producers.