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Primary cerebellopontine progressive multifocal leukoencephalopathy diagnosed premortem by cerebellar biopsy
Author(s) -
Jones H. Royden,
HedleyWhyte E. Tessa,
Freidberg Stephen R.,
Kelleher Joseph E.,
Krolikowski John
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410110218
Subject(s) - progressive multifocal leukoencephalopathy , medicine , cerebellopontine angle , pathology , ataxia , cerebellar ataxia , malignancy , leukoencephalopathy , biopsy , cerebellum , dermatology , disease , multiple sclerosis , radiology , magnetic resonance imaging , immunology , psychiatry
A subacute progressive cerebellar brainstem syndrome developed in a patient with systemic lupus erythematosus in remission. Cerebellar biopsy documented the diagnosis of progressive multifocal leukoencephalopathy (PML). Data from this patient and 10 others in the literature emphasize the need to consider this diagnosis when ataxia develops in any patient with underlying malignancy, chronic infection, or other disease that involves immunological incompetence. Although the ataxic form of PML is not of nosological relevance, early diagnosis may eventually hav therapeutic importance.