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Distemper and multiple sclerosis in Sitka, Alaska
Author(s) -
Cook Stuart D.,
Dowling Peter C.
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410110215
Subject(s) - canine distemper , multiple sclerosis , incidence (geometry) , population , medicine , virus , virology , immunology , environmental health , physics , optics
The annual incidence of multiple sclerosis (MS) in Sitka, Alaska, was determined in the period 1949–1979, spanning a severe 1965 epidemic of canine distemper in the dog population. Three patients were identified, and each had the onset of MS in 1969 or 1970. This time cluster of MS is significant ( p < 0.01) and was predicted by the hypothesis that MS may be linked to canine distemper virus.