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Hematogenous origin of the inflammatory response in acute poliomyelitis
Author(s) -
Wolinsky Jerry S.,
Jubelt Burk,
Burke Susan,
Narayan Opendra
Publication year - 1982
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410110111
Subject(s) - microglia , parenchyma , pathology , encephalitis , inflammatory response , peripheral blood mononuclear cell , inflammation , biology , neuroglia , central nervous system , ultrastructure , poliovirus , cell type , perivascular space , immunology , thymidine , virus , virology , medicine , cell , in vitro , neuroscience , biochemistry , genetics
Abstract To determine the origin of the inflammatory response, and in particular the microglial rod cell response, in acute viral encephalitis, 4‐week‐old Swiss mice were injected with tritiated thymidine to label actively dividing cells prior to infection with the Lansing type 2 strain of poliovirus. As expected, the majority of polymorphonuclear and mononuclear leukocytes within the central nervous system perivascular infiltrates were shown to be hematogenous in origin. As early as 24 hours after infection, isotope‐labeled cells having light histological and ultrastructural features consistent with microglia and microglial rod cells were identified within brain parenchyma and were shown to participate in neuronophagia and formation of glial nodules. Supraependymal and suprachoroidal cells were also shown to contain the label. However, neither endothelial cells nor pericytes contained label as determined by electron microscopy. These studies support a hematogenous origin for all cellular elements of the classic inflammatory response in viral infections of brain.