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Vitamin E deficiency in Werdnig‐Hoffmann disease
Author(s) -
Shapira Yehuda,
Amit Rami,
Rachmilewitz Eliezer
Publication year - 1981
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410100312
Subject(s) - medicine , vitamin e deficiency , disease , vitamin e , pathology , biology , biochemistry , antioxidant
Vitamin E levels were measured in the plasma of infants and children with various neuromuscular disorders. Seven of 8 infants with Werdnig‐Hoffmann disease (WHD) had a singificantly lower plasma vitmin E level ( p < 0.01) than age‐matched normal controls, children with congenital myopathies, or children with muscular dystrophy. Vitamin E deficiency in WHD is not caused by malabsorption. A therapeutic trial of vtamin course of the disease. Vitamin E deficiency may play a role in the pathologenesis of WHD.