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Permanent axotomy, a model of axonal atrophy and secondary segmental demyelination and remyelination
Author(s) -
Dyck Peter James,
Lais Alfred C.,
Karnes Jeannine L.,
Sparks Margaret,
Hunder Heidi,
Low Phillip A.,
Windebank Anthony J.
Publication year - 1981
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410090611
Subject(s) - remyelination , axotomy , ataxia , medicine , atrophy , anatomy , myelin , denervation , pathological , cats , pathology , neuroscience , biology , central nervous system
Permanent axotomy in cats produced by hind limb ablation results in sequential pathological alterations of myelinated fibers of the proximal nerve stump. The changes are like those previously described for human uremic neuropathy and such system atrophies as Friedreich's ataxia; axonal atrophy → myelin wrinkling → nodal lengthening and internodal demyelination → remyelination.