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Local cerebral glucose utilization in thermally traumatized rat brain
Author(s) -
Pappius H. M.
Publication year - 1981
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410090511
Subject(s) - lesion , medicine , brainstem , depression (economics) , cerebral blood flow , deoxyglucose , white matter , cerebral cortex , cortex (anatomy) , pathology , magnetic resonance imaging , neuroscience , psychology , radiology , economics , macroeconomics
Local cerebal glucose utilization (LCGU) Was studied using the 14 C‐deoxyglucose method in rats with focal thermally induced lesions in the left parietal cortex. A depression of LCGU developed with time after production of the lesion, being most prominent throughout the cortical areas of the lesioned hemisphere: 42 ± 2% (SE) of normal 3 days after the lesion, was induced. Corresponding results in other regions were: contralateral cortical areas, 86 ± 2%; ipsilateral and contralateral subcortical structures, 74 ± 2% and 84 ± 1%, respectively. Brainstem structures were not affected. In white matter, bilateral depression LCGU reached its peak 24 hours after production of the lesion—the reduction ipsilateral to the lesion was 61 ± 4% of normal and the contralateral reduction was 64 ± 4%. LCGU returned to normal within 5 days in all affected areas. No corresponding change in local cerebral blood flow were observed. These results suggest a widespread depression in the functional state of the traumatized brain.