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Treatment of fungal infections of the central nervous system
Author(s) -
Bell William E.
Publication year - 1981
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410090502
Subject(s) - miconazole , amphotericin b , ketoconazole , immunosuppression , central nervous system , medicine , antifungal , disease , mycosis , intensive care medicine , immunology , dermatology
The recent development of new antifungal antimicrobials that can be administered in combination with amphotericin B or as alternatives to it has expanded the dimensions of treatment for fungal infections of the central nervous system. These disorders have acquired increasing importance as patients with malignant and other illnesses associated with immunosuppression survive longer and as renal transplantation is more widely applied. Amphotericin B has remained the most effective therapeutic preparation for most types of neurological fungal disease, although important roles for 5‐fluorocytosine, miconazole, and, more recently, ketoconazole are being recognized. Bell WE: Treatment of fungal infections of the central nervous system.