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Spinocerebellar engeneration with parkinsonian features: A clinical and pathological report
Author(s) -
Weir Roger L.,
Fan Kuang J.
Publication year - 1981
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410090118
Subject(s) - substantia nigra , parkinsonism , degeneration (medical) , atrophy , pathological , medicine , spinal cord , pathology , degenerative disease , neuroscience , parkinson's disease , psychology , disease , psychiatry
A 20‐year‐old patient had spinocerebellar ENgeneration and parkinsonian tremor that improved with L‐dopa treatment. Postmortem examination revealed posterior column atrophy in the spinal cord and severe ENgeneration in the substantia nigra. Atrophic changes were noted in ENep cerebellar nuclei and superior cerebellar peduncles. This study confirms the relationships between clinical parkinsonism, substantia nigra atrophy, and the therapeutic effect of L‐dopa.