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Brain tissue from persons dying of creutzfeldt‐jakob disease causes scrapie‐like encephalopathy in goats
Author(s) -
Hadlow William J.,
Prusiner Stanley B.,
Kennedy Richard C.,
Race Richard E.
Publication year - 1980
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410080615
Subject(s) - scrapie , kuru , encephalopathy , disease , slow virus , etiology , virology , virus , transmissible spongiform encephalopathy , medicine , pathology , biology , viral disease , psychiatry , prion protein
Two goats became affected with an encephalopathy indistinguishable from scrapie 43 months after they were inoculated intracerebrally with 10% suspensions of brain from two persons dying of Creutzfeldt‐Jakob disease. Although this observation does not establish the common identity of Creutzfeldt‐Jakob disease virus and scrapie virus, it is thought to provide strong evidence of a close etiological relationship between the two diseases.