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Remyelination following viral‐induced demyelination: Ferric ion—ferrocyanide staining of nodes of ranvier within the CNS
Author(s) -
Weiner L. P.,
Waxman S. G.,
Stohlman S. A.,
Kwan A.
Publication year - 1980
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410080606
Subject(s) - axolemma , remyelination , myelin , staining , pathology , ferrocyanide , nodal , chemistry , node of ranvier , stain , biology , central nervous system , biophysics , anatomy , neuroscience , medicine , electrode
Ferric ion‐ferrocyanide (Fe‐FeCN) staining was used to stain nodes of Ranvier in remyelinating central nervous system (CNS) axons following viral‐induced demyelination. As at normal nodes, Fe‐FeCN staining was observed on the cytoplasmic surface of the nodal axolemma of remyelinated fibers. These fibers were identified on the basis of inappropriately short internode lengths and thin myelin sheaths. Thus, newly formed nodes along remyelinated CNS axons recapitulate at least one normal nodal membrane property.