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Failure to detect abnormal fatty acid profiles in serum lipoproteins in Friedreich's ataxia
Author(s) -
Walker Janet L.,
Chamberlain Susan,
Robinson Norman
Publication year - 1980
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410080113
Subject(s) - ataxia , medicine , lipoprotein , cholesterol , endocrinology , fatty acid , spinocerebellar ataxia , high density lipoprotein , chemistry , biochemistry , psychiatry
Abstract A recent report indicated an association between the spinocerebellar degeneration of Friedreich's ataxia and abnormal fatty acid profiles of the cholesterol ester fraction in both total plasma and high‐density lipoprotein. In an effort to substantiate these findings in lipoproteins, we estimated fatty acid profiles of total high‐density lipoprotein and the cholesterol esters of high‐ and low‐density lipoproteins. Those profiles in 10 Friedreich's ataxia patients compared well with previously reported normal values and did not differ significantly from results in 10 age‐matched controls.