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Progressive central nervous system deterioration: A complication of advanced chronic lung disease of prematurity
Author(s) -
Ellison Patricia H.,
Farina Matthew A.
Publication year - 1980
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410080107
Subject(s) - medicine , hypotonia , apnea , bradycardia , respiratory failure , central sleep apnea , complication , continuous positive airway pressure , pediatrics , brainstem , central nervous system , anesthesia , lung disease , lung , cardiology , surgery , blood pressure , polysomnography , obstructive sleep apnea , heart rate
Fifteen premature infants with severe chronic lung disease of prematurity were treated with ventilatory assistance and continuous positive airway pressure for at least 28 days. Fourteen developed progressive central nervous system deterioration following right heart failure and pulmonary hypertension. Two patterns of deterioration were observed: (1) cerebral, with loss of developmental milestones, increasing hypotonia, and eventual EEG deterioration and death; and (2) brainstem, with progressive apnea, bradycardia, or both, and sudden death or irreversible apnea.