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Interaction of multiple sclerosis serum with liposomes containing ganglioside G M1
Author(s) -
Mullin Brian R.,
Montanaro Anthony J.,
Reid J. D.,
Nishimura Robert N.
Publication year - 1980
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410070615
Subject(s) - multiple sclerosis , liposome , ganglioside , cholera toxin , myelin , central nervous system , immunology , chemistry , medicine , biochemistry , endocrinology
Abstract Multiple sclerosis serum contains a factor or factors capable of releasing sequestered [ 14 C]glucose from liposomes containing G M1 , the major ganglioside present in human central nervous system myelin. Although some control sera can also release large quantities of liposomal glucose, multiple sclerosis and control sera differ in the mechanism of this release. Liposomal damage by multiple sclerosis serum does not appear to be complement mediated, but shares certain releasing characteristics of cholera toxin.