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Normal human sleep: Regional cerebral hemodynamics
Author(s) -
Sakai Fumihiko,
Meyer John Stirling,
Karacan Ismet,
Derman Sabri,
Yamamoto Masahiro
Publication year - 1980
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410070514
Subject(s) - wakefulness , cerebral blood flow , sleep (system call) , hemodynamics , anesthesia , psychology , sleep stages , medicine , electroencephalography , cardiology , neuroscience , polysomnography , computer science , operating system
Measurements of regional cerebral blood flow (rCBF) by the xenon 133 inhalation method along with polygraph recordings were made serially during relaxed wakefulness and different stages of nocturnal sleep in 18 righthanded normal volunteers. During stage I‐II sleep the fast flow (Fg) values declined significantly, more in the brainstem‐cerebellar (BSC) regions than in hemispheric regions. During stage III‐IV sleep, Fg further declined diffusely in both hemispheric (‐28%) and BSC (‐29%) regions. Duringg awakening from stage IV sleep to alpha‐frequency wakefulness, BSC flow values increased more than hemispheric flow values. During REM sleep, regional Fg values increased diffusely in both hemispheric (+41%) and BSC (+47%) regions compared with wakefulness. There was a significant inverse correlation between the increase in end‐tidal partial pressure for carbon dioxide and the reduction in bihemispheric Fg during sleep. Cerebral vasomotor responsiveness to carbon dioxide is decreased during both REM and non‐REM sleep.