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Parkinson disease, dementia, and alzheimer disease: Clinicopathological correlations
Author(s) -
Boller Fraņois,
Mizutani Tomohiko,
Roessmann Uros,
Gambetti Pierluigi
Publication year - 1980
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410070408
Subject(s) - dementia , medicine , autopsy , alzheimer's disease , disease , degenerative disease , parkinson's disease , severe dementia , central nervous system disease , senile plaques , pathology , population , environmental health
Clinical records and neuropathological specimens from 36 patients with autopsy‐demonstrated idiopathic Parkinson disease (PD) were reviewed independently and the results compared. Nine (31%) of the 29 patients with adequate clinical data had severe dementia and 7 (24%) had mild dementia. The cerebral cortex showed senile plaques and fibrillary tangles in 15 of the 36 patients (42%). These changes were found in all 9 patients with severe dementia, in 3 of the 7 with mild dementia, and in 3 of the 13 patients with normal mental status. The prevalence of pathologically established Alzheimer changes and dementia among the patients with PD (33%) was over six times that found in an age‐matched population (5.1%). Survival after the onset of PD with Alzheimer disease was shorter than in PD without Alzheimer disease.