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Mycoplasma antibody in guillain‐barré syndrome and other neurological disorders
Author(s) -
Goldschmidt Barbra,
Mena Joseph,
Fortunato Julei,
Dowling Peter,
Cook Stuart
Publication year - 1980
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410070203
Subject(s) - mycoplasma pneumoniae , complement fixation test , medicine , immunology , mycoplasma , antibody , titer , guillain barre syndrome , encephalitis , counterimmunoelectrophoresis , serology , pneumonia , biology , microbiology and biotechnology , virus
Counterimmunoelectrophoresis (CIEP) was used to determine precipitating antibodies to Mycoplasma pneumoniae retrospectively in sera from 100 patients with Guillain‐Barré syndrome (GBS), 125 medical and neurological controls, and 40 normal individuals. Sera from 7 patients produced precipitin lines. These positive cases included 5 patients with GBS, 1 with acute cerebellar ataxia, and 1 with acute disseminated encephalomyelitis. A complement‐fixation test performed with the same antigen showed titers to M. pneumoniae of 1:512 or greater in these 7 sera. In contrast, sera from other patient controls and normal individuals were negative by CIEP and had only low mycoplasma complement‐fixation antibody titers. No distinguishing clinical features separated the 5 seropositive GBS patients from the whole group except for their young age, which parallels that for human mycoplasma infection in general. Additional laboratory findings consistent with acute mycoplasma infection were demonstrated in 6 of the 7 seropositive patients.