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Huntington's disease: Abnormality of lymphocyte capping
Author(s) -
Noronha Avertano B. C.,
Roos Raymond P.,
Antel Jack P.,
Arnason Barry G. W.
Publication year - 1979
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410060512
Subject(s) - concanavalin a , huntington's disease , lymphocyte , abnormality , disease , medicine , immunology , pathology , gastroenterology , biology , genetics , in vitro , psychiatry
Concanavalin A‐induced lymphocyte capping was studied in 30 patients with Huntington's disease (HD) and 39 controls. A significant decrease in lymphocyte capping was seen in the 24 patients with HD less than 60 years of age compared to 25 age‐matched controls ( p < 0.01); above age 60, differences between patients with HD and controls were not significant. These findings lend support to previous observations that generalized membrane abnormalities are present in patients with HD. Studies of HD lymphocyte capping may permit a detailed analysis of membrane function in cells that are readily obtained from living patients.