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Effects of reserpine, propranolol, and aminophylline on seizure activity and CNS cyclic nucleotides
Author(s) -
Gross Robert A.,
Ferrendelli James A.
Publication year - 1979
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410060403
Subject(s) - pentylenetetrazol , aminophylline , convulsant , reserpine , propranolol , adenosine , medicine , endocrinology , cyclic guanosine monophosphate , chemistry , ictal , phosphodiesterase inhibitor , seizure threshold , cyclic adenosine monophosphate , guanosine , epilepsy , anticonvulsant , biology , biochemistry , neuroscience , nitric oxide , receptor
Convulsant doses of pentylenetetrazol (100 mg/kg) increase levels of both cyclic adenosine monophosphate (AMP) and cyclic guanosine monophosphate (GMP) in mouse cerebral cortex and hippocampus. In animals pretreated with reserpine, propranolol, or aminophylline, pentylenetetrazol seizures were more severe, cyclic AMP elevations were attenuated or blocked, and cyclic GMP increases were unaffected or augmented. These data indicate that norepinephrine, adenosine, and perhaps other biogenic amines have a regulatory effect on cyclic AMP, but not cyclic GMP, levels in epileptic brain. An increased levels of cyclic AMP in brain tissue may have an antiepileptic effect leading to seizure attenuation or termination. By contrast, elevated levels of cyclic GMP may have an antiepileptic effect leading to seizure attenuation or termination. By contrast, elevated levels of cyclic GMP may have an epileptogenic effect in initiating or maintaining seizure activity.