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Search for viral particles and virus‐specific products in idiopathic Parkinson disease brain material
Author(s) -
Schwartz Jerome,
Elizan Teresita S.
Publication year - 1979
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410060314
Subject(s) - virology , virus , measles virus , parkinson's disease , substantia nigra , measles , disease , pathology , medicine , etiology , herpes simplex virus , immunology , biology , vaccination
Virological studies were performed on brain material from 9 patients with idiopathic Parkinson disease and 3 matched controls. Electron microscopy and indirect immunofluorescent study were carried out directly on autopsy material from substantia nigra, caudate nucleus, and hypothalamus and on primary tissue culture explants of these brain areas grown alone or in cocultivation with virus‐susceptible indicator cell lines. All studies were negative for the presence of viral particles, viral inclusions, or cellular changes suggestive of virus infection. All materials were negative for antigens of herpes simplex type 1, influenza A/NWS, and measles (Edmonston strain) viruses. Within the limits of these techniques, there is no evidence at this time that viruses are an important etiological agent in idiopathic Parkinson disease.