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Activity of 2′,3′‐cyclic nucleotide 3′‐phosphohydrolase in human cerebrospinal fluid
Author(s) -
Banik Naren L.,
Mauldin Lawrence B.,
Hogan Edward L.
Publication year - 1979
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410050608
Subject(s) - cerebrospinal fluid , multiple sclerosis , myelin , enzyme , cyclic nucleotide , enzyme assay , nucleotide , demyelinating disorder , chemistry , specific activity , medicine , pathology , biochemistry , endocrinology , immunology , central nervous system , gene
Activity of the myelin marker enzyme 2′,3′‐cyclic nucleotide 3′‐phosphohydrolase (CNP) was assayed in cerebrospinal fluid samples obtained from patients with multiple sclerosis (MS) and other neurological diseases. The enzyme activity was found to be elevated in acute cases of MS and reduced during remission. It was present in other demyelinating diseases, and no activity was detected in normal CSF. CNP may be released into CSF from any insult to myelin. The level of activity appears to reflect demyelination and the rate of breakdown of the myelin sheath.