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Retroperitoneal neuroblastoma widely metastatic to the central nervous system
Author(s) -
Dresler Steven,
Harvey Danny G.,
Levisohn Paul M.
Publication year - 1979
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410050215
Subject(s) - medicine , meninges , autopsy , spinal cord , skull , parenchyma , neuroblastoma , cerebrospinal fluid , pathology , leptomeninges , central nervous system , metastasis , cranial cavity , anatomy , cancer , genetics , psychiatry , biology , cell culture
A girl with congenital extraadrenal neuroblastoma died at 3 months of age with multiple parenchymal metastases in the brain and spinal cord. The bones of the skull, cranial dura, venous sinuses, and orbits were not involved. Autopsy findings suggest that the tumor penetrated the spinal meninges and disseminated through the cerebrospinal fluid. It is possible that hematogenous metastasis occurred as well. The intracerebral metastases were not identified on a CT scan performed several hours before the child's death.