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Acute demyelinating disease in a chimpanzee three years after inoculation of brain cells from a patient with MS
Author(s) -
Rorke Lucy Balian,
Iwasaki Yuzo,
Koprowski Hilary,
Wroblewska Zofia,
Gilden Donald H.,
Warren Kenneth G.,
Lief Florence S.,
Hoffman Steven,
Cummins Larry B.,
Rodriguez Arthur R.,
Kalter Seymour S.
Publication year - 1979
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410050113
Subject(s) - demyelinating disease , medicine , disease , multiple sclerosis , inoculation , virology , immunology , pathology
Brain cells from a patient with classic multiple sclerosis were inoculated intracerebrally into the frontal lobe of a newborn chimpanzee. The animal developed acute quadriplegia three years, two months later and was killed four days after the onset of symptoms. Central nervous system lesions were primarily localized in the spinal cord at root entry zones; these were characterized by demyelination and regeneration of myelin by Schwann cells.