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Comparative cranial CT enhancement in a primate model of cerebral infarction
Author(s) -
Drayer Burton P.,
Dujovny Manuel,
Wolfson Sidney K.,
Boehnke Manfred,
Cook Eugene E.,
Rosenbaum Arthur E.
Publication year - 1979
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410050108
Subject(s) - medicine , abnormality , radiology , cerebral infarction , infarction , middle cerebral artery , contrast enhancement , computed tomography , perfusion , perfusion scanning , contrast medium , nuclear medicine , magnetic resonance imaging , ischemia , cardiology , myocardial infarction , psychiatry
The value of various enhancement techniques as opposed to nonenhanced CT scanning was compared in 15 baboons with cerebral infarction secondary to embolization of the left middle cerebral artery. The most prominent CT findings in infarction included an area of low absorption in the opercula–basal ganglia–centrum semiovale region and generalized lateral ventricular enlargement. Intravenous enhancement of the low‐density region occurred in 25% of the animals and often obscured the preenhancement abnormality. However, a rapid bolus injection of contrast material followed by immediate consecutive CT scans (computed angiotomography) permitted prominent visualization of early‐shunting veins. Delayed scanning following intrathecal enhancement better defined small infarctions that did not exhibit the usual cerebral blush. The CT imaging of inhaled xenon provides a new technique for evaluating subtle abnormalities in cerebral perfusion, even when the routine CT scan shows no abnormality.