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Proteolytic enzyme activity of blood leukocytes and cerebrospinal fluid in multiple sclerosis
Author(s) -
Cuzner M. Louise,
Davison Alan N.,
Rudge Peter
Publication year - 1978
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410040409
Subject(s) - multiple sclerosis , cerebrospinal fluid , proteolytic enzymes , exacerbation , immune system , immunology , myelin , chemistry , cell , myelin basic protein , enzyme , biology , biochemistry , central nervous system , medicine , pathology , endocrinology
Upon stimulation by immune complexes, the polymorphonuclear (PMN) blood cell secretes lysosomal hydrolases, including neutral proteinase, which is concentrated in the PMN cell. Neutral and acid proteinase activity were increased and decreased, respectively, in the circulating white cells of patients with multiple sclerosis during an exacerbation of the disease, but there was no correlation with serum immune complex levels. Neutral proteolytic activity in the cellular fraction of the cerebrospinal fluid was also found to be elevated in acute multiple sclerosis, as monitored by digestion of myelin basic protein.