Premium
HLA antigens in the Landry‐Guillain‐Barré syndrome and chronic relapsing polyneuritis
Author(s) -
Stewart G. J.,
Pollard J. D.,
McLeod J. G.,
Wolnizer C. M.
Publication year - 1978
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410040317
Subject(s) - medicine , human leukocyte antigen , guillain barre syndrome , polyradiculoneuropathy , immunology , chronic inflammatory demyelinating polyneuropathy , antigen , antibody
Forty‐four patients with inflammatory demyelinating polyneuritis (22 with Landry‐Guillain‐Barré syndrome, 6 with subacute polyneuritis, and 16 with chronic relapsing polyneuritis) were typed for genetic markers in and around the HLA region of chromosome 6. Patients with chronic relapsing polyneuritis showed a definite association with HLA‐AW30 and AW31 and probable associations with HLA‐B8, HLA‐DW3, and glyoxalase I. No significant associations were demonstrated with the Landry‐Guillain‐Barré syndrome although an increase in glyoxalase I was significant if combined with the results of typing in chronic relapsing polyneuritis. The total patient group showed significant increases in HLA‐AW30, HLA‐AW31, and HLA‐DW3. The results support the view that HLA‐linked genetic factors influence susceptibility to chronic relapsing polyneuritis and may contribute to the differences in clinical patterns observed in inflammatory demyelination of the peripheral nervous system.