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Relationship of lymphocyte invasion and survival of brain tumor patients
Author(s) -
Brooks W. H.,
Markesbery W. R.,
Gupta G. D.,
Roszman T. L.
Publication year - 1978
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410040305
Subject(s) - lymphocyte , brain tumor , medicine , psychology , immunology , biology , oncology , neuroscience , pathology
The length of survival of 149 patients harboring primary brain tumors was retrospectively correlated with the presence and location of lymphocytic infiltration. Mononuclear invasion of malignant gliomas confined to the perivascular spaces was the only histological finding that correlated significantly with survival. Patients with malignant gliomas containing perivascular infiltration lived up to four months longer than those with no lymphocyte infiltration. The survival of patients with brain tumors who had lymphocyte invasion associated with areas of hemorrhage and necrosis beyond and separate from perivascular spaces was the same as for those with no lymphocyte involvement.