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The cerebrospinal fluid in visna, a slow viral disease of sheep
Author(s) -
Griffin Diane E.,
Narayan Opendra,
Bukowski Jack F.,
Adams Robert J.,
Cohen Steven R.
Publication year - 1978
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410040304
Subject(s) - pleocytosis , cerebrospinal fluid , immunology , csf pleocytosis , medicine , antibody , disease , viral disease , biology , virology , human immunodeficiency virus (hiv) , pathology
The temporal development of the CSF abnormalities was examined in visna, a chronic neurological disease caused by a persistent viral infection of sheep. Two types of changes were observed. During the first 30 to 40 days there was an intense mononuclear pleocytosis associated with high protein and proportionately elevated IgG. Later, there was a persistent slight pleocytosis associated with mildly elevated protein which had an increased proportion of IgG and antivisna antibody. These later cellular and protein changes are similar to those found in a number of chronic neurological diseases of man.