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Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease
Author(s) -
Butterfield D. A.,
Oeswein J. Q.,
Prunty M. E.,
Hisle K. C.,
Markesbery W. R.
Publication year - 1978
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410040111
Subject(s) - huntington's disease , adenosine triphosphatase , triphosphatase , acetylcholinesterase , medicine , atpase , enzyme , endocrinology , sodium , potassium , erythrocyte membrane , membrane , chemistry , biochemistry , biology , disease , organic chemistry
Dopa‐decarboxylase, acetylcholinesterase, sodium plus potassium stimulated adenosine triphosphatase (Na + + K + − ATPase), and membrane‐bound protein kinase were compared in the erythrocytes of patients with Huntington's disease and normal controls. All these enzymes also exist in the basal ganglia. The Na + + K + ‐ATPase level was elevated ( p < 0.05) in Huntington's disease, while no significant changes were observed in the other enzymes. This finding is consistent with the concept that Huntington's disease is associated with a general membrane abnormality.