Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease | Zendy

Butterfield D. A. | Zendy; Oeswein J. Q. | Zendy; Prunty M. E. | Zendy; Hisle K. C. | Zendy; Markesbery W. R. | Zendy

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Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease

Author(s) -

Butterfield D. A.,

Oeswein J. Q.,

Prunty M. E.,

Hisle K. C.,

Markesbery W. R.

Publication year - 1978

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.410040111

Subject(s) - huntington's disease , adenosine triphosphatase , triphosphatase , acetylcholinesterase , medicine , atpase , enzyme , endocrinology , sodium , potassium , erythrocyte membrane , membrane , chemistry , biochemistry , biology , disease , organic chemistry

Dopa‐decarboxylase, acetylcholinesterase, sodium plus potassium stimulated adenosine triphosphatase (Na + + K + − ATPase), and membrane‐bound protein kinase were compared in the erythrocytes of patients with Huntington's disease and normal controls. All these enzymes also exist in the basal ganglia. The Na + + K + ‐ATPase level was elevated ( p < 0.05) in Huntington's disease, while no significant changes were observed in the other enzymes. This finding is consistent with the concept that Huntington's disease is associated with a general membrane abnormality.

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