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Effect of prednisolone on motor end‐plate fine structure: A morphometric study in hamsters
Author(s) -
Chokroverty S.,
Reyes M. G.,
Chokroverty M.,
Kaplan R.
Publication year - 1978
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410030414
Subject(s) - prednisolone , postsynaptic potential , dose , body weight , intraperitoneal injection , endocrinology , wet weight , medicine , anesthesia , anatomy , chemistry , biology , receptor
The fine structure of quadriceps motor end‐plates in hamsters was analyzed quantitatively one, two, four, seven, and thirty‐two weeks following intraperitoneal injections of prednisolone. Except for transient increases in postsynaptic length and membrane profile concentration after prednisolone administration at dosages of 4 mg per kilogram of body weight for one week and 2 mg per kilogram for four weeks, mean values for various measurable profiles in the presynaptic and postsynaptic regions showed no significant differences between control and treated animals.