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Levodopa in Parkinson disease: A long‐term appraisal of mortality
Author(s) -
Joseph Clifford,
Chassan Jacob B.,
Koch MariaLuise
Publication year - 1978
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410030205
Subject(s) - levodopa , parkinsonism , medicine , mortality rate , parkinson's disease , population , disease , pediatrics , environmental health
Mortality rates for a group of patients in a collaborative multicenter study of levodopa (Larodopa) in the treatment of parkinsonism were compared with corresponding mortality rates in the general population adjusted for age and sex distribution in accordance with that of the parkinsonian patients under study. The death rate, conservatively adjusted for dropouts among parkinsonian patients, is estimated to be approximately 33% greater than that for the general population. This is in contrast to an earlier study of Hoehn and Yahr, prior to the advent of levodopa treatment, where in the mortality rate for parkinsonian patients was shown to be in excess of that in the general population by a factor of 2.9 or nearly 200%.