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Creatine kinase BB isoenzyme levels by radioimmunoassay in patients with neurological disease
Author(s) -
Bell Rodney D.,
Rosenberg Roger N.,
Ting Ruby,
Mukherjee Amal,
Stone Marvin J.,
Willerson James T.
Publication year - 1978
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410030108
Subject(s) - radioimmunoassay , cerebrospinal fluid , medicine , creatine kinase , isozyme , endocrinology , gastroenterology , biology , enzyme , biochemistry
Creatine kinase BB (CK‐BB) isoenzyme was measured by radioimmunoassay in serum and in cerebrospinal fluid from 61 patients with various neurological disorders. Statistically significant elevations of CK‐BB isoenzyme in the serum were observed in patients with acute cerebrovascular accidents and in those with seizures and a prolonged alteration in level of consciousness. Statistically significant elevations of CK‐BB isoenzyme in the cerebrospinal fluid were also found in patients who had suffered acute cerebrovascular accidents. Some patients with central nervous system infections, acute demyelinating disease, certain drug overdoses, head trauma, and complex migraine also had elevations of serum and CSF CK‐BB isoenzyme. In 2 patients with elevations of CK‐BB isoenzyme, the elevations in serum occurred later than those detected in the cerebrospinal fluid. If CK‐BB elevations determined by radioimmunoassay can be demonstrated to be quantitatively related to the extent of brain damage, then these determinations in conjunction with experimental animal models and newer radiological techniques should allow evaluation, in an objective and precise manner, of measures designed to decrease that damage.