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The ocular motor defects in progressive supranuclear palsy
Author(s) -
Troost B. Todd,
Daroff Robert B.
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410020509
Subject(s) - smooth pursuit , reflex , eye movement , vestibulo–ocular reflex , progressive supranuclear palsy , palsy , fixation (population genetics) , electrooculography , audiology , abnormality , physical medicine and rehabilitation , psychology , medicine , ophthalmology , neuroscience , population , alternative medicine , environmental health , pathology , atrophy , social psychology
The results of quantitative infrared horizontal eye movement recordings in 8 patients with progressive supranuclear palsy are presented. Some of the patients had total paralysis of vertical movements, but none had completely lost the ability to perform horizontal eye movements. All patients had a defect in ocular fixation previously undescribed in this condition: the universal presence of square‐wave jerks. Analysis of refixation sacades demonstrated hypometria, slow velocity/amplitude relationships, and profound prolongation of duration. The pursuit abnormality, characterized clinically by “cogwheel” eye movements, represented the inability to match eye velocity to target velocity. The ratio of peak eye velocity to peak target velocity (pursuit gain) was 0.2 to 0.5. Defects in the vestibuloocular reflex included inability to increase the gain of the reflex (ratio of peak eye velocity to head velocity) during viewing of a visible, stationary target and failure to suppress the reflex when viewing a target rotating with the head.