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Programmed feeding as a model of chronic alcoholism in the rat
Author(s) -
Craig J. R.,
Munsat T. L.,
Chuang M.
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410020409
Subject(s) - polydipsia , adenosine triphosphatase , ethanol , chronic alcoholic , chronic alcoholism , medicine , endocrinology , rat model , anesthesia , chemistry , atpase , biochemistry , diabetes mellitus , enzyme
Programmed‐feeding polydipsia results in a reliable model of chronic alcoholism in the rat. High oral ethanol consumption and a predictable withdrawal reaction associated with audiogenic seizures are produced. The maintenance of high blood ethanol levels for three weeks in 18 male Charles River rats was associated with audiogenic seizures after 6 to 8 hours of withdrawal. These chronic alcoholic rats had enhanced blood clearance of ethanol. The cerebral cortical crude mitochondrial function showed a decrease in total and magnesium‐dependent adenosine triphosphatase activity in alcoholic and control (water‐fed) rats compared with normal rats.