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Pharmacological prophylaxis against the development of kindled amygdaloid seizures
Author(s) -
Turner Ira M.,
Newman Stephen M.,
Louis Sydney,
Kutt Henn
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410020307
Subject(s) - ethosuximide , kindling , phenobarbital , phenytoin , acetazolamide , medicine , primidone , epilepsy , anesthesia , dexamethasone , anticonvulsant , pharmacology , psychiatry
The kindling of amygdaloid and cortical seizures in cats was used to study the prophylactic effects of phenobarbital, phenytoin, ethosuximide, acetazolamide, and dexamethasone. Phenobarbital prevented the evolution of such seizures beyond stage 4 in all amygdaloid‐kindling animals during 160 days of study. The prophylactic effect persisted on periodic challenge after the drug had been discontinued. Phenytoin, ethousuximide, acetazolamide, and dexamethasone appeared to have no prophylactic effect against the development of kindled amygdaloid seizures. With cortical kindling, both phenobarbital and phenytoin retarded the evolution of seizures without achieving true prophylaxis. The drugs appeared to act as suppressants. Prophylaxis was not an “all‐or‐none” phenomenon but rather a limitation of the stage of seizure evolution.