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Sarcoidosis, galactorrhea, and amenorrhea: 2 Autopsy cases, 1 with chiari‐frommel syndrome
Author(s) -
Brust John C. M.,
Rhee Richard S.,
Plank Charles R.,
Newmark Michael,
Felton Charles P.,
Lewis Linda D.
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410020208
Subject(s) - galactorrhea , medicine , sarcoidosis , autopsy , amenorrhea , pituitary adenoma , immunoperoxidase , pathology , prolactin , adenoma , hormone , pregnancy , antibody , biology , immunology , monoclonal antibody , genetics
Two women with amenorrhea and galactorrhea, 1 with Chiari‐Frommel syndrome, died of cerebral sarcoidosis. At autopsy in both cases, sarcoid granulomas were numerous in the hypothalamus, but the pituitary appeared normal and did not contain increased prolactin as determined by immunoperoxidase technique. These are the first autopsy reports of sarcoidosis with galactorrhea and of Chiari‐Frommel syndrome in the absence of pituitary adenoma.