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Peripheral nerve abnormality in multiple sclerosis
Author(s) -
Pollock Martin,
Calder Christopher,
Allpress Stephen
Publication year - 1977
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410020107
Subject(s) - multiple sclerosis , myelin , pathology , peripheral , myelin sheath , abnormality , sural nerve , medicine , anatomy , peripheral nervous system , central nervous system , immunology , psychiatry
Biopsy specimens of sural nerve from 10 patients with multiple sclerosis (MS), of whom only 1 was severely disabled, were assessed by morphometric techniques and compared to nerves from age‐matched controls. The frequency of abnormal teased fibers was increased in MS nerve, with many intenodes showing at least a 50% reduction in myelin thickness. Myelinated nerve fiber densities were not significantly different in MS and control nerves. Regression analysis of axonal area on number of myelin lamellae indicated a generalized reduction of myelin lamellae in this disorder. It is suggested that peripheral myelin may be involved in multiple sclerosis. Supported by the New Zealand Neurological Foundation, the Medical Research Council, and the National, Otago, and Canterbury Multiple Sclerosis Societies.